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Mutagenesis Duloxetine was not mutagenic in the in vitro bacterial reverse mutation assay Ames test and was not clastogenic in an in vivo chromosomal aberration test in mouse bone marrow cells. Additionally, duloxetine was not genotoxic in an in vitro mammalian forward gene mutation assay in mouse lymphoma cells or in an in vitro unscheduled DNA synthesis UDS assay in primary rat hepatocytes, and did not induce sister chromatid exchange in Chinese hamster bone marrow in vivo. The disabling nature of osteoarthritis pain can greatly impact a persons life, said Vladimir Skljarevski, , a study author and medical fellow at Eli Lilly and Company. As our population ages, osteoarthritis of the knee is likely to become an increasing problem.
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