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When you prescribe fluoxetine, you shouldn t think, I m giving an antidepressant, rather than I m giving an anti-anxiety/PTSD/impulsivity reducer that also is sometimes used for depression. Or, any combination of that? If someone thinks that fluoxetine has an inherent anti-depressant mechanism, this is truly concerning. Duloxetine Hydrochloride works as a serotonin and norepinephrine reuptake inhibitor, with a higher affinity for both of these neurotransmitters receptors than a number of other antidepressants. Patients usually observe significant pain relief within a week of taking the drug, and the half-life is thought to be around eight to twelve hours, with most of the metabolites excreted through the urine or faeces. As the clinical trials have all been short-term, and the collection of data from patients who have been using Cymbalta since 2004 has either not been collected or collated in a systematic way amenable to analysis, there remains significant concern over the drugs long-term effects on both natural neurotransmitter levels and the health of the liver. Serious withdrawal symptoms have been noted amongst users weaning themselves off Cymbalta, as with other SSRIs, leading to campaigns against the drug, and a mushrooming of websites and blogs detailing individuals personal experiences with this medication.
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