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Drugs Metabolized by CYP1A2 In vitro drug interaction studies demonstrate that duloxetine does not induce CYP1A2 activity. Therefore, an increase in the metabolism of CYP1A2 substrates, theophylline, caffeine resulting from induction is not anticipated, although clinical studies of induction have not been performed. Although duloxetine is an inhibitor of the CYP1A2 isoform in in vitro studies, the pharmacokinetics of theophylline, a CYP1A2 substrate, were not significantly affected by co-administration with duloxetine 60 mg BID. Duloxetine is thus unlikely to have a clinically significant effect on the metabolism of CYP1A2 substrates. Reproductive System and Breast Disorders Frequent: anorgasmia/orgasm abnormal; Infrequent: menopausal symptoms and sexual dysfunction; Rare: menstrual disorder.
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