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A depressed individual show signs such as loss of interest in fun activities, general low moods. Depression is a disorder that has medical treatment. There are four main types of depression disorders: Major depressive disorder, Clinical depression, unipolar depression and major depression. One can be diagnosed by use of clinical instrument such as major depression inventory which have been design to detect major depression in patients. Cymbalta has an enteric coating that resists dissolution until reaching a segment of the gastrointestinal tract where the pH exceeds 5.5. In extremely acidic conditions, Cymbalta, unprotected by the enteric coating, may undergo hydrolysis to form naphthol. Caution is advised in using Cymbalta in patients with conditions that may slow gastric emptying, some diabetics. Drugs that raise the gastrointestinal pH may lead to an earlier release of duloxetine. However, co-administration of Cymbalta with aluminum- and magnesium-containing antacids 51 mEq or Cymbalta with famotidine, had no significant effect on the rate or extent of duloxetine absorption after administration of a 40 mg oral dose. It is unknown whether the concomitant administration of proton pump inhibitors affects duloxetine absorption see WARNINGS AND PRECAUTIONS.
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