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Patients with major depressive disorder MDD, both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior suicidality or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide. There has been a long-standing concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. Maintaining regularity with consumption of the drug brings about best results.
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