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Hansen R, Gaynes B, Thieda P, Gartlehner G, Deveaugh-Geiss A, Krebs E, Lohr K. The evidence from clinical trials shows that Cymbalta significantly reduced chronic pain in comparison to placebo, with more than 29, 000 patients with osteoarthritis, or chronic low back pain involved in these clinical trials. The four major trials involved in the analysis of the drugs efficacy and safety were double-blind, placebo-controlled, randomized clinical trials RCTs, providing the highest class of rigorous scientific investigation into new drug therapies. These RCTs were, however, short-term, and the FDA expressed concerns over approving a pain - relief medication that had some serious side-effects associated with it including potential liver damage.
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