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You really shouldnt ever stop an SSRI/SSNRIs cold turkey. How come some of you chose to do that? Orthostatic hypotension and syncope have been reported with therapeutic doses of duloxetine. Syncope and orthostatic hypotension tend to occur within the first week of therapy but can occur at any time during duloxetine treatment, particularly after dose increases. The risk of blood pressure decreases may be greater in patients taking concomitant medications that induce orthostatic hypotension such as antihypertensives or are potent CYP1A2 inhibitors see Warnings and Precautions 5.11 and Drug Interactions 7.1 and in patients taking duloxetine at doses above 60 mg daily. Consideration should be given to discontinuing duloxetine in patients who experience symptomatic orthostatic hypotension and/or syncope during duloxetine therapy.
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