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Cymbalta duloxetine hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor SSNRI for oral administration. Its chemical designation is - S-N-methyl- - 1-naphthyloxy-2thiophenepropylamine hydrochloride. The empirical formula is C Because CYP2D6 is involved in duloxetine metabolism, concomitant use of duloxetine with potent inhibitors of CYP2D6 may result in higher concentrations of duloxetine. Paroxetine 20 mg QD increased the concentration of duloxetine 40 mg QD by about 60%, and greater degrees of inhibition are expected with higher doses of paroxetine. Similar effects would be expected with other potent CYP2D6 inhibitors, fluoxetine, quinidine.
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