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Patients should be cautioned about the concomitant use of duloxetine and NSAIDs, aspirin, warfarin, or other drugs that affect coagulation since combined use of psychotropic drugs that interfere with serotonin reuptake and these agents has been associated with an increased risk of bleeding see Warnings and Precautions 5.5. I tried last year to ween off Cymbalta and I was in so much pain I called the doctor for a new prescription. My doctor suggested I might have fibromyalgia and Cymbalta claims to help this too.
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