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It was so reassuring to read your posts and have you describe the same things I am feeling. The scariest part for me is when I move my eyes or head and get that funny feeling. Thank God, I have the most understanding husband that has walked every step of this horrible trail with me. I could not imagine going thru this alone. I thought I had been battling the flu, a bacterial thing or heaven-forbid parasites Have had diarhhea for 5 weeks, about the time I was finishing up the Lexapro, and really getting going with the Cymbalta. Even had samples sent to the lab. Nothing. Biotransformation and disposition of duloxetine in humans have been determined following oral administration of 14 C-labeled duloxetine. Duloxetine comprises about 3% of the total radiolabeled material in the plasma, indicating that it undergoes extensive metabolism to numerous metabolites. The major biotransformation pathways for duloxetine involve oxidation of the naphthyl ring followed by conjugation and further oxidation. Both CYP2D6 and CYP1A2 catalyze the oxidation of the naphthyl ring in vitro. Metabolites found in plasma include 4-hydroxy duloxetine glucuronide and 5-hydroxy, 6-methoxy duloxetine sulfate. Many additional metabolites have been identified in urine, some representing only minor pathways of elimination. Only trace 1% of the dose amounts of unchanged duloxetine are present in the urine. Most about 70% of the duloxetine dose appears in the urine as metabolites of duloxetine; about 20% is excreted in the feces.
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