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Numerous cases of hyponatremia have been reported following treatment with a selective serotonin reuptake inhibitor SSRI. Risk factors for the development of SSRI associated hyponatremia including advanced age, female gender, concomitant use of diuretics, low body weight, and lower baseline serum sodium levels have been identified. Hyponatremia tends to develop within the first few weeks of treatment range 3 to 120 days and typically resolves within 2 weeks range 48 hours to 6 weeks after therapy has been discontinued with some patients requiring treatment, water restriction, dietary sodium. The proposed mechanism for the development of hyponatremia involves the syndrome of inappropriate secretion of antidiuretic hormone SIADH via release of antidiuretic hormone. My experience with Cymbalta has been mostly a positive one. My primary physician put me on it when I was crying in his office and stating I felt there was no hope of relieving chronic back pain. Initial side effects including urinary hesitany was frightening but did not last. Some fatigue and persistent dry mouth are still present two years later. However, I feel very much in control of my emotions and pretty upbeat. I havent felt that way in years. And I sleep very well. The pain improved significantly, also. I suddenly have been diagnosed with high cholesterol and low iron stores, also, which now I read are side effects. I might like to have children some day. I am frightened by the weening I would need to do. But for now, my life is so much better with cymbalta.
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