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Featured Conditions We welcome you to share your experiences. Current Topics: Painkiller Addiction, Anxiety, Panic Attacks, It is generally agreed that acute episodes of major depression require several months or longer of sustained pharmacologic therapy. Maintenance of efficacy in MDD was demonstrated with Cymbalta as monotherapy. Cymbalta should be administered at a total dose of 60 mg once daily. Patients should be periodically reassessed to determine the need for maintenance treatment and the appropriate dose for such treatment see Clinical Studies.
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