I\'ve been on topamax along with zoloft and pamelor for more then a year now. The zoloft I have been taking for some 15 years. Topamax has really worked for me, I have lost 35 lbs in a years time and has been the best combo with the other meds. I have been on Lithium and etc. over the last 15 years. I am sold on the topamax.