I was on Effexor for over a year, and weaned myself from 300mg down over many months. My Md tried to wean me too fast and I had horrible withdrawal symptoms, so put myself back on and weaned myself very slowly. At 37.5 mg I just could not go the rest of the way and my new Md(needless to say I left the one who prescribed it in the first place) told me to just go cold turkey and not turn back. Well, its been almost three weeks now and I have suffered terrible depression and anxiety to the point where I am unable to work. Its embarrassing to be out because I start weeping uncontrolably anywhere and anytime. This is far worse than when I went on the medication in the first place. Does anyone know if this will eventually end? My MD wants to start me on another antidepressant, but who is to say that will not be the same story all over again. I may feel better emotionally but have side effects like Migraines, facial tics, loss of appetite and weight, insomnia, and extreme fatigue.