I\'ve been on Effexor for nearly 2 years now and have also put on about 20 pounds. Nothing I seem to do will budge any weight - I exercise daily and eat the right thiings - its really frustrating. The effexor was just great to get me back on track after experiencing debilitating panic attacks. My dr told this was the result of seretonin deficiency and it was weight neutral but this has not been the case for me. I\'m on 150mg and plan to wean myself off it and try and get my metabolism back to normal. Hopefully my panic attacks won\'t return - I\'ll just try and get lots of sleep and get my seretonin naturally. I\'ve also heard that taking Omega3 with vitamin E is supposed to be good for elevating your moods naturally. Will keep you posted and hopefully will lose the blubber I\'ve put on. It\'s good to know I\'m not the only one to experience this.