I feel your pain sister! I have been on Effexor for about 3 years. I have since been in counselling and have been weaning myself off. It has taken me a year and I am down to 37.5 dose. I feel ok, but the thing I am most depressed about is my weight gain. I am working out daily and eating right, with no results. I am really hoping once I am off completely, it will start to fall off.