I have been on Celexa for depression(nerves)for 2yrs.and had hysterectomy in Nov.04,and on Premarin 1.25 since then. I have gained about 20 lbs.since last Nov. I believe its my hormone. I am going to try to go off Celexa and get on Adipex (diet pill) and see what happens. I know at 34 y.o. I need my hormone. I may not can handle getting off the Celexa, but I\'m going to try my hardest. Good luck to you.