Posted by Chris Maloney, ND on 03/19/04 at 08:46 PM
I just did a scan of the medline literature on Topamax. This is an FDA approved drug for epilepsy, and I don’t think any large scale studies have been done on weight loss. When it is used with bipolar patients, weight loss is see as a side effect. I also did not find any studies on depression and Topamax. It did seem to help migraine. The side effects include psychosis, confusion, and 2-4 times the risk of kidney stones. My overall impression is that this is a drug in its “honeymoon”” period and we don’t have any good data on what the long term effects will be.